- cleft.ie - http://www.cleft.ie -
Posted By admin On May 7, 2007 @ 2:35 pm In Uncategorized | Comments Disabled
There are some 400 known syndromes associated with cleft lip and/or palate. A study (1970) 1 by F. C. Fraser noted that approximately 3% of all cases of clefting were associated with known syndromes. A Danish study (1988) 2 indicated a figure of 4.3% and concluded that this figure probably underestimated the true frequency with which other anomalies were associated with facial clefting. A study carried out in Singapore (1999) 3 indicated that associated congenital deformities occurred in 1.5% of the total cleft population.
Other studies have reported figures which may not be directly comparable with those listed above. A French investigation by Stoll et al (2000) 4 indicated that of 460 cleft infants born in Northeastern France between 1979 and 1996, 36.7% had associated malformations. A Portuguese study (1999) 5 of 284 patients indicated that 27.5% had associated malformations. Analysis of data for the Magdeburg region in Germany (1998) 6 indicated that 22% of all children with oral clefts had additional malformations.
Note: The large differences in the figures reported above may be due to the distinction between what constitutes a syndrome and what constitutes a malformation. A syndrome is where a number of conditions exist together, while referral to associated malformations may actually indicate a single condition existing in association with a cleft. [Eddie Byrne]
Article printed from cleft.ie: http://www.cleft.ie
URL to article: http://www.cleft.ie/related-syndromes/
URLs in this post:
 Image: #listen
 1: #footnote_0_332
 2: #footnote_1_332
 3: #footnote_2_332
 4: #footnote_3_332
 5: #footnote_4_332
 6: #footnote_5_332
 ↩: #identifier_0_332
 ↩: #identifier_1_332
 ↩: #identifier_2_332
 ↩: #identifier_3_332
 ↩: #identifier_4_332
 ↩: #identifier_5_332
Copyright © 2008 cleft.ie. All rights reserved.