Incidence
Posted on March 22nd, 2007
Incidence of facial clefts in the Magdeburg region of Germany
[Original Abstract]1
Reports on the incidence of oral clefts in Germany over long periods do not exist because there has been no continuous system of registering malformations in place. However, since 1980 there has been such a system of registration in place in Magdeburg, which, with a population of 1.5 million, has had a yearly birth rate of approximately 8000.
Study of data for the region indicates that there has been a very high rate of oral clefts, mainly a cleft lip with or without a cleft palate, with a rate of 1.85 per 1000 births, ie. 1:540.
22% of all children with oral clefts had additional malformations. Heart defects accounted for the highest occurrence at about 10%.
A peak occurrence of neural tube defects from 1987 to 1989 resulting in increased incidence of clefts in 1988 and 1989 may be a causal factor in the high overall incidence reported.
Facial clefts from 1961 to 2000–incidence, prenatal diagnosis and prevalence by maternal age
[Research Report - Original Abstract]2
The retrospective demographic epidemiological study reports on the incidence of cleft lip with or without cleft palate in the Czech Republic during the period 1961 to 2000.
Data from the Institute for the Care of Mother and Child in Prague (period 1961-1990) were used as well as data from the nationwide registration of birth defects of infants ensured by the Institute of Health Information and Statistics of the Czech Republic covering the period 1987-2000. Epidemiological analysis of the incidence of cleft lip with or without cleft palate diagnosed in the Czech Republic during 1961-2000, and mathematical statistical analysis of the prevalence of these defects by maternal age, the method of calculation of the 95% confidence limit of probability was used.
RESULTS: From a consecutive series of 5,589,888 births in the Czech Republic during 1961-2000, 1166 cases of cleft lip, 5052 cases of cleft lip and palate were diagnosed and 3970 cases of cleft palate. A total of 10,188 cases of facial clefts were recorded. The mean incidence of cleft lip during the investigation period was 2.09 per 10,000 liveborn infants, the incidence of cleft lip with/without cleft palate was 11.13 per 10,000 liveborn infants. The mean incidence of cleft palate during the investigation period was 7.10 per 10,000 liveborn infants and of facial clefts as a whole 18.23 per 10,000 liveborn infants.
CONCLUSION: The authors provided evidence that the frequency of facial clefts as a whole during the investigation period did not undergo significant changes as regards the trend of incidence. When evaluating maternal age as one of the risk factors for the development of facial clefts the investigation confirmed a greater risk in 15 year-old women and women older than 35 years, without exception.
The Incidence of Cleft Lip and Palate in Northern Ireland
SEE: The Incidence of Cleft Lip and Palate in Northern Ireland from 1980-1990
Gregg, T. Boyd, D., and Richardson, A. (1994)
- Rosche, C., Steinbicker, V., Rose, I. (1998) [Incidence of facial clefts in the Magdeburg region] [Article in German] Mund Kiefer Gesichtschir. Jan, 2(1):5-10. Abstract (in English) available at http://www.ncbi.nlm.nih.gov (National Library of Medicine - PubMed . Do search on title words to retrieve abstract). [accessed 3 August 2000] [↩]
- A Sipek, V Gregor, J Horacek, and D Masatova. [Facial clefts from 1961 to 2000–incidence, prenatal diagnosis and prevalence by maternal age] Ceska Gynekol, September 1, 2002; 67(5): 260-7. Original article in Czech [↩]
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