Associated Anomalies
Posted on March 22nd, 2007
Associated malformations in cases with oral clefts - French study.
[Summary]1
The purpose of this French investigation (2000) was to assess the prevalence of associated malformations among the 460 cleft infants born in Northeastern France between 1979 and 1996 (out of a total 238,942 births). Of the 460 cleft infants, 36.7% are reported as having associated malformations. These were most frequent in infants with cleft palate only (46.7%), as against infants with cleft lip and palate (36.8%), or infants with cleft lip only (13.6%). Malformations in the central nervous system and in the skeletal system were the anomalies most commonly associated. Next in frequency were malformations in the urogenital and cardiovascular systems. Although prenatal ultrasonic tests were rarely carried out, in instances where such tests were carried out, a success rate of only 31.6% is reported in diagnosis. The report concluded that routine screening for associated malformations in cleft babies ought to be considered, and genetic counselling seemed warranted in most cases.
The range of congenital malformations associated with cleft lip and palate - Portuguese study
This study2Â (1999) examined 284 cleft patients referred to the Cleft Consultation of Dona Estefania Hospital in Lisbon, Portugal, and reported that 27.5% (n=78) had associated malformations. The most frequent associated malformations were those of the face (25.9%) and of the cardiovascular system (16.5%).
- Stoll, C., Alembik, Y., Dott, B., Roth, M.P. (2000) Associated malformations in cases with oral clefts. Cleft Palate Craniofacial Journal. January 2000, 37(1);41-7. [↩]
- Duarte, R., Leal, M.J. (1999) [The range of congenital malformations associated with cleft lip and palate]. [Article in Portuguese] Acta Med Port 1999 Apr-Jun, 12(4-6):147-54. Abstract (in English) available at http://www.ncbi.nlm.nih.gov - National Library of Medicine - PubMed . Do search on title words to retrieve abstract [↩]
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